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Relationship between VEGF Gene 936^*T/C Polymorphism and Gastric Cancer
Author(s): 
Pages: 33-35,74
Year: Issue:  5
Journal: journal of putian university

Keyword:  VEGFgastric cancergene polymorphism;
Abstract: 研究血管内皮生长因子(VEGF)936^*T/C基因多态性与胃癌之间的关系,了解该基因多态性对胃癌生成及发展的影响。采用聚合酶链反应一限制性片段长度多态性(PCR-RFLP)方法检测胃癌患者和健康者外周血的VEGF936。T/C基因型。结果,胃癌患者外周血中VEGF936。T/C基因型或等位基因与健康者相比无差异(精确概率法计算基因型P=0.226;卡方检验等位基因x^2=2.934,P=0.087)。Ⅲ、Ⅳ期病理分期患者C/C基因型和c等位基因比例(66.7%和82.0%)明显大于Ⅰ、Ⅱ期(12.9%和1.2%),两者差异有统计学意义(基因型:x^2:14.215,P=0.000;等位基因:X2=28.430,P=0.000)。结果表明,VEGF9360C/C基因多态性与胃癌的生成无关,而与胃癌的进展相关。
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