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Relationship between HPV Genotype and Cervical Lesions
Author(s): 
Pages: 42-45
Year: Issue:  5
Journal: journal of putian university

Keyword:  human papillomavirusgenotypecervical lesionssequence analysis;
Abstract: 了解莆田地区女性感染人乳头状瘤病毒(HPV)基因型分布情况及其与宫颈病变的关系。采用核酸分子快速导流杂交基因分型芯片(HybriMax)和液基薄层细胞学(LCT)技术对345例女性宫颈脱落细胞进行HPV基因分型和细胞学检测;同时用基因序列测定检证HybrMax技术的可靠性;对LCT结果为HSIL及以上细胞学异常的患者161例在阴道镜下行组织病理学活检。结果表明,莆田地区女性患者感染HPV阳性率为40.6%,且HPV基因型具有一定的区域性特点;宫颈病变各组之间高危HPV感染率的差异具有显著性统计学意义(x^2=16.040,P=0.003〈0.01),且高危型HPV感染与宫颈病变程度呈正相关。
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