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ANG1005, a new type polypeptide targeted low-density lipoprotein receptor-related protein 1 in blood-brain barrier
Author(s): 
Pages: 396-399
Year: Issue:  4
Journal: Drugs & Clinic

Keyword:  ANG1005Angiopep-2紫杉醇低密度脂蛋白受体相关蛋白-1血脑屏障脑瘤;
Abstract: 很多抗癌药物由于血脑屏障的限制对脑瘤作用比较差,不利于药物的吸收.紫杉醇是二萜类天然产物,其在体外能有效地抑制恶性脑胶质瘤的生长,但并不能显著提高恶性脑胶质瘤患者存活时间,其原因主要是紫杉醇在血浆中消除太快,血脑屏障渗透能力差等导致肿瘤部位吸收过低.为了解决这个问题,一种可靶向低密度脂蛋白受体相关蛋白-1(LRP-1)的19个氨基酸的肽Angiopep-2与3分子紫杉醇结合构成ANG1005,ANG1005与LRP-1结合作用后可以促使受体介导的药物通过跨细胞转运进入脑组织中.
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