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Salt type selection strategy in research and development of new drugs
Author(s): 
Pages: 414-417
Year: Issue:  4
Journal: Drugs & Clinic

Keyword:  新药候选化合物盐型溶解度生物利用度晶型;
Abstract: 在新药研发早期阶段,将候选化合物成盐是一种重要手段,可改善候选化合物的理化性质,如溶解度、结晶度、吸湿性、熔点和固态稳定性等.药物盐型的筛选首先从反离子的选择开始,然后筛选结晶条件制备其相应的盐型,最后根据结晶度、熔点、吸湿性、物理化学稳定性和晶型等因素确定药物的最终盐型.药物盐型的筛选对选择具有适宜药学性质的固态剂型有重要的指导作用.
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