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Effect of porcine encephalomyocarditis virus infection on iNOS mRNA transcription level
Author(s): 
Pages: 686-691
Year: Issue:  9
Journal: Chinese Journal of Preventive Veterinary Medicine

Keyword:  脑心肌炎病毒iNOSmRNA转录水平致病机制;
Abstract: 为研究iNOS在猪脑心肌炎病-毒(EMCV)致病机制中的作用,本研究将猪源EMCV GXLC株人工感染小鼠、仔猪,观察临床症状和病理变化,检测心、脑组织中iNOS mRNA转录水平.试验结果表明,小鼠和仔猪感染EMCV后均出现明显的临床症状、剖检及组织病理学变化显示心、脑组织的病理炎症分值显著增加;心、脑组织中的iNOS mRNA转录水平显著上调,并且转录水平上调的峰值与感染小鼠、仔猪出现明显临床症状、严重病理损害及小鼠死亡高峰存在明显的时间相关性,与心、脑组织的病理炎症分值成线性正相关.表明组织中iNOS的过量表达与感染动物的发病和死亡密切相关,iNOS在EMCV致病机制中发挥重要作用.
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