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Retrospective assessment of anti-coagulative therapy and the incidence of acute coronary syndrome during perioperative period in high-risk patients who had suffered percutaneous coronary intervention recentely
Author(s): 
Pages: 780-782
Year: Issue:  5
Journal: Journal of Peking University(Health Sciences)

Keyword:  血管成形术经腔经皮冠状动脉抗凝药围手术期急性冠状动脉综合征;
Abstract: 目的:分析经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后患者行非心脏手术围术期早期抗凝治疗与急性冠状动脉综合征(acute coronary syndrome,ACS)发生的关系.方法:回顾2009年5月至2011年5月于北京安贞医院行择期非心脏手术的患者资料,其中有135名患者于手术前1年内曾行PCI,且PCI术后坚持口服阿司匹林及氯吡格雷(波立维).择期手术前予肝素替代治疗,术后分为未抗凝组(63例)、低分子肝素抗凝组(34例)及普通肝素抗凝组(38例),观察术后3日内ACS的发生情况及出血情况.结果:3组患者中未抗凝组有9人(14.3%)于术后3日内出现ACS,低分子肝素抗凝组及普通肝素抗凝组均无ACS患者出现(P<0.01).3组患者的术后输入库存血量差异无统计学意义.结论:近期行PCI术的高危患者在行择期非心脏手术术后早期给予有效的抗凝治疗,可以明显降低围术期ACS的发生率,且并不增加术后出血的风险.
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