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Expression of parafibromin in human osteosarcoma of the jaws
Author(s): 
Pages: 792-796
Year: Issue:  5
Journal: Journal of Peking University(Health Sciences)

Keyword:  骨肉瘤纤维瘤骨化性Parafibromin蛋白;
Abstract: 目的:检测parafibromin蛋白在人颌骨骨肉瘤(osteosarcoma of the jaws,JOS)中的表达情况,探讨其在JOS的发生、发展中的作用.方法:采用免疫组织化学的方法检测parafibromin蛋白在47例JOS和11例颌骨骨化纤维瘤(ossifying fibroma of the jaws,JOF)中的表达情况.结果:JOS中,parafibromin高表达、中等表达、低表达患者分别占48.9% (23/47)、40.4%( 19/47)和10.7% (5/47);JOF中,三者所占的百分率分别为90.9%( 10/11)、9.1%(1/11)和0.0%(0),与JOS相比,差异有统计学意义(U=147.5,P=0.012);parafibromin在高分化型JOS中的表达水平高于传统型JOS(U=71.0,P=0.021);parafibromin的表达情况与临床病理参数间无相关性(P>0.05).结论:parafibromin蛋白在JOS中表达下调,这种表达的减少可能与JOS的分化和恶性程度有关.
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