Studies on the actions of Xiefei Dingchuan injection(泻肺定喘注射液) on Ca2＋Mg2＋ATPase and Na＋K＋ATPase of red blood cell membrane in rats with pulmonary hypertension induced by monocrotaline
Author(s): XIONG Xudong, Shen Xiaohong
Pages: 3-5
Year: 2001 Issue: 1
Journal: CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE IN INTENSIVE AND CRITICAL CARE
Keyword: 野百合碱; 肺动脉高压; 孔雀绿比色法; Ca2+Mg2+ATP酶; Na+K+ATP酶; 泻肺定喘注射液; 中医药;
Abstract: To investigate the mechanism of Xiefei Dingchuan injection (XFDCI,泻肺定喘注射液) in treating pulmonary hypertension by means of measuring the activity of Ca2＋Mg2＋ ATPase and Na＋K＋ATPase of red blood cell(RBC) membrane.Methods:The pulmonary hypertension models induced by monocrotaline in 18 rats were established then treated with XFDCI.Using cardiac catheter and chromatometry respectively the pulmonary artery pressure (PAP) and the activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane were measured.Results:The activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane in XFDCI group were obviously higher than those in pulmonary hypertension group.Conclusions:XFDCI is able to reduce the pulmonary hypertension and its mechanisms may be related to increasing the activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane.
Pages: 3-5
Year: 2001 Issue: 1
Journal: CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE IN INTENSIVE AND CRITICAL CARE
Keyword: 野百合碱; 肺动脉高压; 孔雀绿比色法; Ca2+Mg2+ATP酶; Na+K+ATP酶; 泻肺定喘注射液; 中医药;
Abstract: To investigate the mechanism of Xiefei Dingchuan injection (XFDCI,泻肺定喘注射液) in treating pulmonary hypertension by means of measuring the activity of Ca2＋Mg2＋ ATPase and Na＋K＋ATPase of red blood cell(RBC) membrane.Methods:The pulmonary hypertension models induced by monocrotaline in 18 rats were established then treated with XFDCI.Using cardiac catheter and chromatometry respectively the pulmonary artery pressure (PAP) and the activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane were measured.Results:The activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane in XFDCI group were obviously higher than those in pulmonary hypertension group.Conclusions:XFDCI is able to reduce the pulmonary hypertension and its mechanisms may be related to increasing the activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane.
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