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Association of vascular endothelial growth factor expression with angiogenesis and tumor cell proliferation in human lung cancer
Author(s): MA Xiaochun, ZHANG Ling, MA Hong, YU Runjiang
Pages: 32-
35
Year: 2001
Issue:
1
Journal: ZHONGHUA NEIKE ZAZHI
Keyword: 肺肿瘤; 内皮生长因子; 新生血管化; 病理性; 肿瘤内微血管密度;
Abstract: Objective To evaluate the expression of vascular endothelial growth factor (VEGF) and the relation with angiogenesis and tumor cell proliferation in human lung cancer. Methods Expression of VEGF, angiogenesis, tumor cell proliferation in 63 cases of human lung cancer were examined immunohistochemically. Anti-VEGF165-Ab3 was used for VEGF expression, a monoclonal antibody directed against CD34 to identify intratumoral microvessel density (iMVD) and the proliferating cell nuclear antigen (PCNA) as a marker of proliferating tumor cells.Results Positive staining for VEGF was obtained in 32 of the 63 cases (50.8%), iMVD varied from 4 to 138.7(M=36)/×400 and the proportion of PCNA positive cells varied from 0 to 92%(M=25.03%). iMVD in high-grade VEGF tumors was significantly higher than that in VEGF-negative tumors and low-grade VEGF tumors. PCNA labeling proliferation index in small cell lung cancer was higher than that in non-small cell lung cancer . iMVD significantly increased with increasing VEGF expression. Conclusion There is VEGF expression in lung cancer. VEGF expression is significantly associated with iMVD, but there is no association between iMVD or VEGF expression and PCNA expression. There is no association between VEGF expression and histological classification and clinical stages.
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