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Journal Articles
Synthesis and biofilm inhibition evaluation of 5-acylated 3,4-dichloro-5H-furan-2-one as quorum sensing autoinducer analogs of Pseudomonas aeruginosa
Pages: 520-523,557
Year: Issue:  7
Journal: Chinese Journal of Antibiotics

Keyword:  群体感应生物膜呋喃酮铜绿假单胞菌;
Abstract: 合成铜绿假单胞菌群体感应信号分子类似物作为细菌生物膜抑制剂.以呋喃甲醛为原料合成5-羟基-3,4-二氯-2(5H)-呋喃酮,与不同长度碳链的烷酸5-位成酯,合成了8个5-烷酸酯基-3,4-二氯-2(5H)-呋喃酮,其结构经NMR和MS表征.初步生物活性测试结果表明,化合物2c,2d,2e,2f和2h对铜绿假单胞菌生物膜的形成有明显的抑制作用,尤其是化合物2e,对ATCC 27853的生物膜抑制率高达70%以上.
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