Author(s): QIAO En-qi, TANG Jin-hai, WU Jian-zhong
Pages: 489-492
Year: 2012 Issue:  7
Journal: Journal of International Oncology
Keyword:  Drug resistance; neoplasm; P-glycbprotein; Pregnane X receptor;
Abstract: P-糖蛋白(P-gP)及其编码基因mdrl的过表达是肿瘤多药耐药(MDR)的经典机制.研究发现,孕烷X受体(PXR)可介导P-gp的表达,已证实PXR还具有抑制肿瘤细胞凋亡作用.因此,特异性地阻断PXR的活化可能是阻止MDR的新方法.