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Effect of testosterone on pathophysiology of lung inflammatory injury following intracerebral hemorrhage
Author(s): 
Pages: 59-61
Year: Issue:  1
Journal: Journal of Apoplexy and Nervous Diseases

Keyword:  脑出血肺损伤睾酮氟他胺白细胞介素-1β肿瘤坏死因子-α;
Abstract: 目的 探讨睾酮在脑出血大鼠急性脑、肺损伤发生、发展中的作用及可能机制.方法 (1)雄性Wiser大鼠55只,分为对照组、脑出血组和氟他胺预处理组.(2)立体定向技术自体血尾状核注入法制作脑出血大鼠模型;氟他胺预处理组大鼠行氟他胺溶液灌胃(50mg/kg·d)10d后,行脑出血造模;对照组大鼠尾状核注入等量生理盐水.(3)ELISA法测定睾酮及TNF-α、IL-1β含量.(4)HE染色光镜观察大鼠脑...
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