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Effects of Total Flavone of Metasequoia glyptostroboides on Left Ventricular Hypertrophy in Renovascular Hypertensive Rats
Author(s): 
Pages: 837-839
Year: Issue:  11
Journal: CHINESE TRADITIONAL AND HERBAL DRUGS

Keyword:  木杉总黄酮高血压左室肥厚;
Abstract: 目的:研究水杉总黄酮对肾性高血压大鼠左室肥厚的预防作用.方法:二肾一夹法建立大鼠肾性高血压心肌肥厚模型,术后第4周,不同剂量的水杉总黄酮ig给药,持续5周.结果:水杉总黄酮(400,40 mg/kg.d)能显著降低 HW/BW、LVW/ BW、心肌纤维直径、左心室肌 Ca2+含量,对大鼠收缩压无显著性影响.结论:水杉总黄酮对肾性高血压大鼠左室肥厚有预防作用,机制可能与钙拮抗作用有关.
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