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Anti-tumor efficacy of sunitinib derivative: ZH26
Author(s): 
Pages: 275-280
Year: Issue:  5
Journal: World Clinical Drugs

Keyword:  ZH26抗肿瘤舒尼替尼舒尼替尼衍生物;
Abstract: 目的 研究舒尼替尼衍生物ZH26的抗肿瘤作用.方法 采用甲基噻唑比色法体外检测ZH26对多种肿瘤细胞株的生长抑制作用;建立S180肉瘤、Colon26结肠癌小鼠肿瘤模型和裸鼠人体肿瘤移植瘤NCI-H460人大细胞肺癌移植瘤、SPC-1肺腺癌移植瘤模型,评价ZH26的体内抗肿瘤活性.结果 ZH26体外对多株肿瘤细胞株有较好的抑制作用,对大多数肿瘤细胞株的IC50值为3.33~5.68 μg/mL,与...
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