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Advance in research on a novel target for the anti-Gram negative bacteria infections, deacetylase LpxC and its inhibitors
Author(s): 
Pages: 298-302
Year: Issue:  5
Journal: World Clinical Drugs

Abstract: 脱乙酰基酶(LpxC)是催化革兰阴性菌外膜脂多糖主要成分类脂A的关键酶,其结构和序列与各种哺乳动物蛋白都不同源.此酶为有效的药物作用靶点,其缺失或过表达都会使某些革兰阴性致病菌死亡.本文综述LpxC的结构、酶学性质、催化机制及其抑制剂等研究进展.
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