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xin xing lu fen hua he wu 3 ,4 - er zuo ji -3- lv er ben jia tong dui da shu que xue / zai guan zhu xin ji de bao hu zuo yong
Author(s): 
Pages: 967-969
Year: Issue:  8
Journal: Research of Traditional Chinese Medicine

Keyword:  3’4’-二羟基-3-氯二苯甲酮 缺血/再灌注 心肌保护 大鼠;
Abstract: 目的明确新型卤酚化合物3’,4’-二羟基-3-氯二苯甲酮(LM46)对缺血/再灌注损伤后大鼠心肌的保护作用。方法利用大鼠心脏局部缺血/再灌注模型,检测LM46处理后大鼠心肌梗死面积和血清酶学指标的变化。结果在再灌注早期静脉给予LM46能有效减轻心肌缺血/再灌注损伤。表现为梗死面积减小,超氧化物歧化酶(SOD)活力升高,显著降低血清乳酸脱氢酶(LDH)、肌酸激酶(CK)、丙二醛(MDA)水平。结论在5mg/kg~15mg/kg剂量范围内,LM46有显著的心肌保护作用。
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