Effects of Fentanyl on Induction Characteristics and MAC of Desflurane during Endotracheal Intubation
Author(s): GU Miaoning, XU Jianshe, LIU Gaowang, CHEN Zhongqing
Pages: 440-441
Year: 2000 Issue: 9
Journal: THE JOURNAL OF CLINICAL ANESTHESIOLOGY
Keyword: Desflurane Fentanyl MAC;
Abstract: Objective and Methods:The study was done to evaluate the effect of fentanyl on the induction characteristicsand MAC of desflurane during endotracheal intubation (MACEI50) in the patients anesthetized with desflurane(group D) ordesflurane plus fentanyl(group F). Results: Loss of consciousness was in 2.4 min (group D) and 2.5 min(group F) respec-tively. The rapid increase of desflurane concentration resulted in coughing( 57 % ), laryngospasm( 50 % ), and significant incre-ments of MAP and HR during gaseous induction. In contrast, coughing and laryngospasm were rare, and MAP and HR re-mained stable during fentanyl plus desflurane induction. MACEI50 was significantly reduced from 1.9MAC during gaseous in-duction to 1.1 MAC during fentanyl plus desflurane induction. Conclusion: Induction of anesthesia with desflurane is rapid,but associated with a high incidence of airway and cardiovascular stimuli during gaseous induction. Fentanly attenuates airwayand cardiovascular response to desflurane and produces a decrease in the MACEI50 of desflurane.
Pages: 440-441
Year: 2000 Issue: 9
Journal: THE JOURNAL OF CLINICAL ANESTHESIOLOGY
Keyword: Desflurane Fentanyl MAC;
Abstract: Objective and Methods:The study was done to evaluate the effect of fentanyl on the induction characteristicsand MAC of desflurane during endotracheal intubation (MACEI50) in the patients anesthetized with desflurane(group D) ordesflurane plus fentanyl(group F). Results: Loss of consciousness was in 2.4 min (group D) and 2.5 min(group F) respec-tively. The rapid increase of desflurane concentration resulted in coughing( 57 % ), laryngospasm( 50 % ), and significant incre-ments of MAP and HR during gaseous induction. In contrast, coughing and laryngospasm were rare, and MAP and HR re-mained stable during fentanyl plus desflurane induction. MACEI50 was significantly reduced from 1.9MAC during gaseous in-duction to 1.1 MAC during fentanyl plus desflurane induction. Conclusion: Induction of anesthesia with desflurane is rapid,but associated with a high incidence of airway and cardiovascular stimuli during gaseous induction. Fentanly attenuates airwayand cardiovascular response to desflurane and produces a decrease in the MACEI50 of desflurane.
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