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Determination of related substances in telmisartan by elution gradient RP-HPLC
Author(s): 
Pages: 229-231
Year: Issue:  3
Journal: World Phytomedicines

Keyword:  替米沙坦有关物质高效液相色谱梯度洗脱;
Abstract: 目的 建立替米沙坦中有关物质的测定方法.方法 采用反相高效液相色谱(RP-HPLC)法,使用Dikma Diamonsil C18色谱柱(150mm×4.6 mm,5μm),[磷酸二氢钾-戊烷磺酸钠缓冲液(pH 3.0)]-[甲醇-乙腈(20∶80)]线性梯度洗脱,检测波长为230 nm,体积流量为1.0 mL/min,柱温为35℃.结果 在上述色谱条件下,5种杂质能与替米沙坦有效地分离,分离度大...
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