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Expression of extracellular matrix metalloproteinase inducer in the unstable plaque of patients with acute coronary syndrome
Author(s): WANG Bin, XU Sha-sha, JIANG Jian-jun, LU Xian-ben, XUE Ying-sheng, WANG Jiao-chen, MI Ya-fei, ZHU Min, GE Wei-li, TANG Li-jiang
Pages: 416-
420
Year: 2012
Issue:
5
Journal: Chinese Journal of Cardiology
Keyword: Coronary disease; Leukotriene B4; Macrophages; Extracellular matrix metalloproteinase inducer;
Abstract: 目的 研究白三烯B4( LTB4)及基质金属蛋白酶诱导因子(EMMPRIN)与冠状动脉不稳定斑块的关系,以及LTB4对巨噬细胞EMMPRIN表达的影响,探讨它们在急性冠状动脉综合征(ACS)中的临床意义.方法 采用免疫组织化学法检测11例入冠状动脉标本EMMPRIN的表达.细胞实验分为8组,第1组为THP-1细胞(THP-1组),2~8组为THP-1源性巨噬细胞(THP-1细胞经佛波酯诱导24h后...
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