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Effect of blocking PI3K/AKT pathway by wortmannin on hypoxia-inducible factor 1α and glycolysis in esophageal carcinoma
Pages: 164-169
Year: Issue:  3
Journal: Chinese Journal of Digestion

Keyword:  glycolysis1-Phosphatidylinositol 3-kinaseHypoxia-inducible factor 1alpha subunitEsophageal neoplasmsAnoxia;
Abstract: 目的 探讨人食管癌细胞TE1、TE13中应用wortmannin阻断PI3K/AKT通路对缺氧诱导因子(HIF)-1α的抑制效果及对糖酵解相关基因表达的影响,分析PI3K/AKT-HIF-1α途径对食管癌细胞糖酵解通路之间的关系.方法 wortmannin(2μmol/L)预处理食管癌细胞TE1、TE13后常氧和缺氧培养,分为①常氧组(N);②缺氧组(H);③常氧处理组(N+W);④缺氧处理组(H...
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