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mRNA and protein expression of skeletal DHPRα1 and RyRs in diaphragm muscle of rabbits
Author(s): 
Pages: 497-501
Year: Issue:  6
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  膈肌钙释放单位DHPRRyRCa2+;
Abstract: 本文测定了兔膈肌钙释放单位中骨骼肌型DHPRα1-亚单位和RyRs的mRNA与蛋白表达水平, 探讨了兔膈肌钙释放单位的结构组成特征.采用RT-PCR、原位杂交和免疫组织化学技术, 分别测定兔膈肌骨骼肌型 DHPRα1- 亚单位和RyR1、RyR2及RyR3的 mRNA 与蛋白表达.结果显示, 兔膈肌可见较高水平的骨骼肌型α1-亚单位和RyR1 mRNA 与蛋白表达; 较低水平的RyR3 mRNA与蛋白表达.表明兔膈肌钙释放单位由骨骼肌型 DHPR、 RyR1和RyR3构成, Ca2+释放可能具有变构耦联和CICR耦联两种形式, RyR3的存在可能是膈肌ECC依赖于细胞外Ca2+的主要原因.
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