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GRADE guidelines: 7.Rating the quality of evidence——inconsistency
Pages: 1444-1451
Year: Issue:  12
Journal: Chinese Journal of Evidence-Based Medicine

Keyword:  GRADE不一致性异质性变异性亚组分析交互作用;
Abstract: 本文针对二分类变量结局指标相对(而非绝对)治疗效果的不一致性.证据本身不会因不同研究结果具有一致性而升级,但可能冈不一致而降低质量级别.衡量一致性的标准包括点估计值的相似性、可信区间的重合程度以及统计学判定标准包括异质性检验和I2.系统评价作者应提出并检验少数几个与患者、干预措施、结局指标以及方法学相关的先验假设以探寻异质性来源.当不一致性很大且无法解释时,因不一致性而降低质量级别是恰当的,特别当...
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