Author(s): Tsann-Long Hwang, Shu-Fang Huang, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Tsann-Long Hwang, Department of Medicine, Chang Gung University, Taoyuan 333, Taiwan Li-Yu Lee, Department of Pathology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Chee-Chan Wang, Chi-Ming Wu, Department of Cosmetic Science, Vanung University, Chungli 320, Taiwan Ying Liang, Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan
Pages: 1249-1256
Year: 2012 Issue:  11
Journal: World Journal of Gastroenterology
Keyword:  CC chemokine;  Chemokine ligand 7;  Chemokine ligand 21;  Gastric cancer;  Lymph node metastasis;  Poor prognosis;
Abstract: AIM:To investigate how a complex network of CC chemokine ligands(CCLs) and their receptors influence the progression of tumor and metastasis.METHODS:In the present study,we used immunohistochemistry to examine the expression of CCL7,CCL8 and CCL21 in 194 gastric cancer samples and adjacent normal tissues.We analyzed their correlation with tumor metastasis,clinicopathologic parameters and clinical outcome.RESULTS:We found that the higher expression of CCL7 and CCL21 in cancer tissues than in normal tissues was significantly correlated with advanced depth of wall invasion,lymph node metastasis and higher tumor node metastasis stage.Moreover,Kaplan-Meier survival analysis revealed that CCL7 and CCL21 overexpression in cancer tissues was correlated with poor prognosis.CONCLUSION:These results suggest that overexpression of these two CC chemokine ligands is associated with tumor metastasis and serves as a prognostic factor in patients with gastric cancer.