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Effects of cilostazol on cochlear blood flow and hearing threshold shift in guinea pigs after noise exposure
Author(s): 
Pages: 4385-4387
Year: Issue:  24
Journal: The Journal of Practical Medicine

Keyword:  西洛他唑噪声耳蜗血流ABR阈值;
Abstract: 目的:探讨在强噪声条件下,磷酸二酯-3A(phosphodiasterase-3A,PDE3A)特异性抑制剂西洛他唑(cilostazol)对豚鼠耳蜗血流及听阈偏移的影响.方法:将40只雄性豚鼠随机分为4组(每组10只):对照组、无噪声给药组、强噪声不给药组,强噪声给药组.强噪声组给予4 KHz的倍频窄带噪声(105 dB SPL)处理13 h.处理后立即腹腔注射西洛他唑(10mg/kg),分别测...
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