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The progress of high-level resistance to aminoglycosides caused by 16S rRNA methylases
Pages: 463-468
Year: Issue:  5
Journal: Experimental and Laboratory Medicine

Abstract: 16S rRNA甲基化酶能够造成对包括阿贝卡星在内的所有氨基糖苷类抗生素耐药,并且为高水平耐药.自2003年在革兰阴性杆菌临床分离株中发现第一个质粒介导的16S rRNA甲基化酶ArmA以来,已发现7种质粒介导的16S rRNA甲基化酶,包括ArmA、RmtA、RmtB、RmtC、RmtD、RmtE和NpmA.16S rRNA甲基化酶基因通常和ESBL基因位于同一可转移的质粒上,造成多重耐药.世界...
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