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Advance in Animal Models of Traumatic Brain Injury
Author(s): LI Shang-xun, WANG Bo-wei, LIU Dan, HE Guang-long, WANG Hao, DUAN Yi-jie, XING Jing-jun, ZHOU Hong-yan, ZHOU Yi-wu
Pages: 286-
289,294
Year: 2011
Issue:
4
Journal: Journal of Forensic Medicine
Keyword: 法医病理学; 脑损伤; 综述[文献类型]; 模型; 动物;
Abstract: 创伤性脑损伤(traumatic brain injury,TBI)是多因素作用的高度复杂过程,TBI动物实验研究有利于阐明TBI原发性、继发性损伤机制及病理生理学过程,为诊断及治疗提供依据.动物模型的选择依赖于研究目的,然而各种动物模型均具有局限性,仅能复制TBI关键的损伤机制或某一重要的病理生理学过程而无法全面反映人脑TBI的特征.本文将TBI动物模型分为直接动态性脑损伤、间接动态性脑损伤、联...
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