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Influence of lupus-induced drugs on immune functions of mice
Author(s): 
Pages: 316-319
Year: Issue:  4
Journal: JOURNAL OF BEIJING MEDICAL UNIVERSITY(HEALTH SCIENCES)

Keyword:  狼疮诱导药物抗体抗核普鲁卡因胺/药理学肼屈嗪(肼苯哒嗪)/药理学;
Abstract: 目的:建立药物诱导狼疮(drug-induced lupus, DIL)的动物模型,研究狼疮诱导药物对小鼠免疫功能的影响.方法:用普鲁卡因酰胺(procainamide, Pca)、盐酸肼苯哒嗪(hydralazine, Hyd)和2,2′-偶氮-双(3-乙苯基-噻唑啉-6-硫酸)诱导DIL的动物模型.用3H-TdR参人法分析细胞增殖,流式细胞分析法分析细胞表型.结果:Pca和Hyd能诱导BALB/C小鼠而不是C57BL/6小鼠产生抗核抗体.对用药BALB/C小鼠的免疫功能(包括对外来抗原的免疫应答、外周血中淋巴细胞的分型等)的分析发现其部分免疫功能的异常.结论:狼疮诱导药物能够导致BALB/C小鼠部分免疫功能的紊乱.
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