Author(s): HAO Ji-fu1, 4, FANG Xin-sheng2, WANG Jian-zhu1, GUO Feng-guang1, KONG Zhi-feng1, PENG Xin-sheng3 1.College of Pharmacy, Taishan Medical University, Tai’an 271016, China 2.College of Agronomy, Shandong Agriculture University, Tai’an 271018, China 3.College of Pharmacy, Guangdong Medical College, Dongguan 523808, China 4.College of Pharmacy, Shandong University, Jinan 250012, China
Pages: 2221-2225
Year: 2011 Issue:  11
Journal: Chinese Traditional and Herbal Drugs
Keyword:  水飞蓟素;  Box-Behnken实验设计;  固体脂质纳米粒;  效应面法;  乳化蒸发-低温固化法;
Abstract: 目的应用Box-Behnken实验设计,优化水飞蓟素固体脂质纳米粒的最佳处方。方法采用三因素三水平Box-Behnken实验设计,以水飞蓟素为模型药物,采用乳化蒸发-低温固化法制备固体脂质纳米粒。利用效应曲面法对影响固体脂质纳米粒包封率、载药量和粒径的主要因素进行考察,以包封率、载药量和粒径为响应值,建立相应的二项式数学模型优化处方。结果最优处方为固体脂质纳米粒中脂质单硬脂酸甘油酯量为5.05%,7.25%Poloxmer 188作为乳化剂,药物的量为15%。结论采用Box-Behnken实验设计可用于水飞蓟素固体脂质纳米粒的处方优化筛选。