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Expression of peroxisome proliferator activated receptor (PPAR-?) in ovary tissue of rat model with polycystic ovarian syndrome and its implication
Pages: 3646-3649
Year: Issue:  20
Journal: The Journal of Practical Medicine

Keyword:  过氧化物酶增殖物激活受体-γ多囊卵巢综合征动物模型卵巢组织;
Abstract: 目的:探讨过氧化物酶增殖物激活受体-γ(PPAR-γ)在多囊卵巢综合征(PCOS)大鼠卵巢的表达与其性激素变化及胰岛素抵抗(IR)的关系.方法:应用脱氢表雄酮(DHEA)皮下注射23日龄SD雌性大鼠20 d,观察卵巢巢重量及光镜(HE染色)形态学改变,应用ELISA(酶联免疫法)测定T、E2、LH、FSH及血清胰岛素、糖耐量试验,应用荧光定时定量聚合酶链反应(real-time PCR)检测PPA...
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