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Effects of intracerebroventricular injection of angiotensinⅡ on blood pressure and discharges of habenula nucleus cardiovascular neurons
Author(s): 
Pages: 347-350
Year: Issue:  4
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  应激性高血压侧脑室注射微离子电泳血管紧张素Ⅱ[Sar1Thr8]-AⅡ;
Abstract: 实验观察了侧脑室注射(icv)及缰核(habenula nucleus Hb)内微电泳血管紧张素Ⅱ(AⅡ)与[Sar1,Thr8]-AⅡ(ST-AⅡ, AⅡ拮抗剂)对正常和应激性高血压(stress-induced hypertension SIH)大鼠血压及内外侧缰核(MHb、LHb)内心血管神经元放电活动的影响.结果如下: icv AⅡ或ST-AⅡ, 正常鼠和SIH大鼠血压均升高或降低, SIH鼠较正常鼠血压变化更显著(P<0.05); icv AⅡ或微电泳AⅡ明显增强Hb内心血管神经元的放电活动, 对SIH大鼠作用更明显; 而微电泳ST-AⅡ则明显抑制Hb内心血管神经元的放电活动, 对SIH大鼠的抑制作用更强.研究表明: 中枢内AⅡ参与SIH的形成, SIH大鼠Hb内心血管神经元对AⅡ反应的敏感性提高了.
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