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Bufalin and oxaliplatin inhibiting proliferation and induced apoptosis of gastric cancer cell line MGC-803
Pages: 3303-3306
Year: Issue:  17
Journal: Chinese Journal of Gerontology

Keyword:  蟾蜍灵奥沙利铂胃癌凋亡BaxBcl-2;
Abstract: 目的 研究蟾蜍灵联合奥沙利铂诱导人胃癌细胞株MG C803凋亡及对凋亡因子Bax、Bcl-2的影响.方法 应用MTr法检测不同浓度蟾蜍灵及奥沙利铂单药及联合对胃癌细胞MGC803增殖抑制作用;流式细胞术分析细胞凋亡和周期阻滞;Western印迹法检测Bax、Bcl-2蛋白的表达.结果 (1)蟾蜍灵及奥沙利铂单药均抑制MGC803细胞增殖,呈剂量时间依赖效应,且联合用药的细胞增殖抑制率高于单药组,差...
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