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Inhibition effects of transplantation of bone marrow stromal cells modified by GDNF gene on neural cell apoptosis in rats with intracerebral hemorrhage
Pages: 731-736
Year: Issue:  6
Journal: Acta Anatomica Sinica

Abstract: 目的 探讨移植胶质细胞源性神经营养因子(GDNF)基因修饰的骨髓基质干细胞(BMSCs)对大鼠脑出血后神经细胞凋亡及凋亡相关基因表达的影响.方法 通过脑立体定位仪向SD大鼠脑尾壳核注射胶原酶和肝素建立脑出血动物模型,将48只模型大鼠随机分为BMSCs组、GDNF/BMSCs组和生理盐水组,各组又根据细胞移植后再喂养时间的不同(1周、2周)分为2个亚组,每亚组8只大鼠.于建模后第3天在脑出血部位分别...
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