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The clinical observation of oxalipclatin combined with leucovorin and 5-Fluorouracil and hydroxycamptothecine for the patients with advanced colorectal cancer
Author(s): 
Pages: 26-27
Year: Issue:  15
Journal: CENTRAL PLAINS MEDICAL JOURNAL

Keyword:  晚期大肠癌羟基喜树碱草酸铂亚叶酸钙5-氟尿嘧啶化学治疗;
Abstract: 目的 观察羟基喜树碱联合草酸铂(艾恒)、亚叶酸钙和5-氟尿嘧啶(5-Fu)组成的HLFO方案治疗晚期大肠癌的疗效和毒副反应.方法 31例晚期大肠癌患者:艾恒150 mg/m2(第1天),亚叶酸钙100 mg/m2,5-Fu 500 mg/m2,羟基喜树碱10 mg/m2,连用5 d,21 d为1周期,每个病例至少接受2个周期化疗.结果 31例患者中完全缓解(CR)2例(15.5%),部分缓解(PR)10例(32.2%),稳定(SD)11例(35.4%),进展(PD)8例(11.1%),总有效率RR(CR+PR)12例(47.7%),该方案主要毒性反应为骨髓抑制和神经毒性,白细胞下降(67.7%),其中Ⅲ、Ⅳ度为25.8%,有61.3%出现周围神经病.结论 该方案具有较好的疗效和耐受性,能提高患者生活质量.
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