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The investigation of the function of TM8 of GLT-1 during the transport cycle
Pages: 2910-2913
Year: Issue:  16
Journal: The Journal of Practical Medicine

Keyword:  谷氨酸TM8区段底物转运结构变构;
Abstract: 目的:探讨TM8区段在谷氨酸转运体GLT-1转运底物过程中所负功能.方法:将GLT-1的TM8区段的氨基酸残基(Thr460-Val483)分别突变为半胱氨酸,然后应用生物化学的方法检测突变体转运活性,巯基试剂MTSET对突变体转运活性的影响以及底物、抑制剂对MTSET抑制效应的影响.结果:1463C、V467C及A468C对MTSET非常敏感;L465C、L466、V469C及W471C对MTS...
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