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Effects of pimecrolimus on the melanogenesis in human malanocytes
Author(s): 
Pages: 527-529
Year: Issue:  8
Journal: China journal of Leprosy and Skin Diseases

Abstract: 目的:评价吡美莫司在体外对人表皮黑素细胞酪氨酸酶活性及黑素生成的影响.方法:培养人原代表皮黑素细胞,利用四甲基偶氮唑蓝(MTT)还原法测定细胞活力,采用酶学方法测定酪氨酸酶活性,氢氧化钠法测定黑素含量.结果:随着剂量的增高,1 nmol/L、10 nmol/L、100 nmol/L及1μmol/L吡美莫司对黑素细胞的酪氨酸酶活性(分别为112.87%,117.29%,120.49%和123.97%...
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