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Over-expression of proto-oncogene Wip1 in intracranial ependymomas association with P53
Author(s): 
Pages: 430-434
Year: Issue:  4
Journal: Basic & Clinical Medicine

Abstract: 目的 探讨野生型P53-诱导的蛋白磷酸酶1(Wip1)在室管膜瘤中的表达及其与P53相关性.方法 用免疫组织化学、反转录聚合酶链反应(RT-PCa)和Western blot 方法检测31例室管膜瘤及10例正常脑组织中Wip1mRNA、蛋白表达.并用免疫组化检测P53.同时,回顾性分析临床病理因素与Wipl表达之间的相关性.结果 室管膜瘤中Wipl阳性表达率为19/31(60%),显著高于正常脑组...
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