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Issue:
Cardiovascular protective effects of metformin
Author(s):
FANG Li-juan
,
LIU Nai-feng
Pages:
232
-
236
Year:
2011
Issue:
2
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Keyword:
二甲双胍
;
动脉粥样硬化
;
心衰
;
心肌梗死
;
Abstract:
二甲双胍(Metformin)属双胍类药物,作为口服降糖药应用于2型糖尿病(T2DM)已有50年的历程,其降糖作用已得到公认.近年越来越多的研究发现,二甲双胍具有降糖以外的心血管保护作用,能抑制动脉粥样硬化(Atherosclerosis,AS)、心衰、心肌梗死等心血管病的发生和发展.但二甲双胍确切的心血管保护机制仍不明确,本文综述了二甲双胍对心血管疾病的作用,并探讨其可能的作用机制.
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