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Influence of Unilateral Testicular Torsion on Contralateral Testis and the Protective Effect of Safflower Injection
Author(s): 
Pages: 26-30
Year: Issue:  5
Journal: Guangdong Trace Elements Science

Keyword:  红花 睾丸扭转 对侧睾丸损伤;
Abstract: 为探讨大鼠单侧睾丸扭转对未扭转侧睾丸生精功能的影响及红花对未扭转侧睾丸早期损伤的保护作用,将21只健康雄性青春期前SD大鼠随机均分为假手术对照组(A组,n=7)、睾丸扭转复位组(B组,n=7)和睾丸扭转复位+红花组(C组,n=7)。按Turner法建立睾丸扭转模型,喂养至术后7 d时处死,即刻采集各组大鼠未扭转侧睾丸标本,测定了睾丸组织丙二醛(MDA)水平、超氧化物歧化酶(SOD)和白细胞介素-6(IL-6)含量,同时进行了组织病理学观察。结果表明,与B组相比,C组MDA值、IL-6含量明显下降,SOD活性明显升高,病理学上表现为平均曲细精管直径明显升高,而睾丸结构评分则明显偏低,两组间比较均有统计学差异(P<0.05)。提示:红花注射液能够减轻大鼠单侧睾丸扭转复位后对侧睾丸的早期损害,其机制可能与减少自由基产生及抗脂质过氧化作用有关。
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