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Expression of tyrosine hydroxylase and retinal disease
Author(s): LIU Zheng-hai, WAN Wei△
Pages: 2168-
2171
Year: 2011
Issue:
11
Journal: Biomagnetism
Keyword: 酪氨酸羟化酶; 多巴胺; 多巴胺能无长突细胞;
Abstract: 酪氨酸羟化酶(tyrosine hydroxylase,TH)是儿茶酚胺(catecholamines,CAs)合成过程中的限速酶,提高或抑制该酶的活性可大幅度影响CAs的合成。近年来对于TH的关注越来越多,大量的研究表明,TH含量及活性的异常改变能通过影响CAs的含量而导致相应生理功能的异常,从而导致疾病。本文将TH的结构功能、分布、表达变化及其与视网膜疾病关系做一综述。
Citations
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