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The Discovery of Fungicide Pyraoxystrobin
Author(s): 
Pages: 173-174
Year: Issue:  3
Journal: Agrochemicals

Keyword:  中间体衍生化方法唑菌酯杀菌活性霜霉病;
Abstract: 概述了运用中间体衍生化方法发现杀菌剂唑菌酯(SYP-3343)的过程:以取代毗唑环替换丁香菌酯结构中的香豆素环,设计并合成了一系列化合物,发现先导化合物(2),通过优化研究发现多个高活性化合物,最终发现了(E)-2-(2-((3-(4-氯苯基)-1-甲基-1H-吡唑-5-基氧基)甲基)苯基)-3-甲氧基丙烯酸甲酯,即唑菌酯(SYP-3343),其具有广谱的杀菌活性,对蔬菜和作物的多种病害如霜霉病、...
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