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Effect of mild hypothermia on the expression of hypoxia-inducible factor-1a and glucose transporter-1 in a rat model of chronic cerebral ischemia-reperfusion
Author(s): 
Pages: 91-94
Year: Issue:  1
Journal: Chinese Journal of Anesthesiology

Keyword:  HypothermiainducedReperfusion injuryBrainHypoxia-inducible factor 1alpha subunitGlucose transporter type 1;
Abstract: 目的 探讨亚低温对大鼠慢性脑缺血再灌注时缺氧诱导因子-1α(HIF-1α)和葡萄糖转运蛋白-1(GLUT-1)表达的影响.方法 健康清洁级雌性SD大鼠36只,体重170~210 g,采用随机数字表法,将大鼠随机分为3组(n=12):假手术组(S组)、常温再灌注组(NT组)和亚低温再灌注组(MH组).除S组外,其余2组采用右侧颈总动脉与右侧颈外静脉端端吻合6周恢复灌注的方法制备大鼠慢性脑缺血再灌注模...
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