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Issue:
Ezrin-associated signal transduction in tumor invasion and metastasis
Author(s):
WANG You-yuan
,
LI Jing-song
,
CHEN Wei-liang
Pages:
166
-
169
Year:
2011
Issue:
3
Journal:
Journal of International Oncology
Keyword:
Phosphoproteins
;
Neolpasm metastasis
;
Prognosis
;
Signal transduction
;
Abstract:
埃兹蛋白(Ezrin)是一种重要的膜-细胞骨架连接分子,在骨肉瘤、乳腺癌等常见的恶性肿瘤中异常表达,并与肿瘤侵袭转移和预后有关,其作用机制复杂,根据组织细胞类型不同,涉及黏附分子信号途径、Rho、Akt等多条肿瘤相关的信号途径.因此,研究埃兹蛋白相关的肿瘤信号转导对认识肿瘤的进展有重要意义,埃兹蛋白可能成为新的肿瘤治疗靶点.
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