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Ezrin-associated signal transduction in tumor invasion and metastasis
Author(s): 
Pages: 166-169
Year: Issue:  3
Journal: Journal of International Oncology

Keyword:  PhosphoproteinsNeolpasm metastasisPrognosisSignal transduction;
Abstract: 埃兹蛋白(Ezrin)是一种重要的膜-细胞骨架连接分子,在骨肉瘤、乳腺癌等常见的恶性肿瘤中异常表达,并与肿瘤侵袭转移和预后有关,其作用机制复杂,根据组织细胞类型不同,涉及黏附分子信号途径、Rho、Akt等多条肿瘤相关的信号途径.因此,研究埃兹蛋白相关的肿瘤信号转导对认识肿瘤的进展有重要意义,埃兹蛋白可能成为新的肿瘤治疗靶点.
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