Author(s): Feng Yongliang, Huang Ling, Xiao Yuxiu
Pages: 1617-1619
Year: 2010 Issue:  11
Journal: China Pharmacist
Keyword:  葛根素; 脂质体; 冷冻干燥; 包封率;
Abstract: 目的:制备注射用葛根素脂质体并刚定其包封率.方法:采用薄膜分散一冷冻干燥法制备葛根素脂质体;加入甘露醉作为冻干保护剂;用正交试验优选处方;用透析法分离游离药物;高效液相色谱法侧定含量.结果:制得的脂质体平均拉径为296 run,Zeta电位为一37.5 mV,包封率(72.4±1.6)% (n=3).在选定的色谱条件下,葛根素与辅料能完全分离,在3.2-72.0.l.Lg-ml范围内,药物浓度与峰...