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Research progress on myofibroblasts: their sources and roles in liver fibrogensis
Author(s): 
Pages: 297-300
Year: Issue:  3
Journal: Chinese Pharmacological Bulletin

Keyword:  肝纤维化肌成纤维细胞肝星状细胞骨髓间充质干细胞上皮-间质转化外周血细胞;
Abstract: 肝脏慢性损伤,包括病毒性肝炎、酗酒、药物作用、代谢性疾病等各种致病因子导致肝内结缔组织异常增生,肝内细胞外基质过度沉淀形成肝纤维化,在此过程中分泌胶原能力更强且具有收缩能力的肌成纤维细胞的大量生成被认为是肝纤维化发生与发展的关键环节.目前对于肝纤维化时肌成纤维细胞来源的认识尚没有完全明了,在肝纤维化发生时肝星状细胞活化为肌成纤维细胞的主要来源;而骨髓间充质干细胞、上皮细胞经上皮间质转化及一些仍具有...
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