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Valsartan improves the cognition impairment in diabetic mice and underlying mechanism
Pages: 405-409
Year: Issue:  3
Journal: Chinese Pharmacological Bulletin

Keyword:  Aβ40Aβ42BACE1;
Abstract: 目的 研究缬沙坦对糖尿病小鼠认知功能的影响及其作用机制.方法 给小鼠静脉注射链脲佐菌素(150 mg·kg-1)诱导1型糖尿病模型,挑选空腹血糖>11.1 mmol·L-1小鼠随机分为3组,即模型组、缬沙坦高剂量组(40 mg·kg-1·d-1)及低剂量组(10 mg·kg-1·d-1),并设正常对照组.每组动物10~14只,灌胃给药,4周后用Morris水迷宫试验评价认知功能,用ELISA分析血...
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