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Mechanism of decreased transcriptional activity of Nurr1 induced by α-synuclein over-expression
Pages: 308-311
Year: Issue:  3
Journal: Chinese Pharmacological Bulletin

Keyword:  GSK3β/β-catenin转录活性PC12细胞;
Abstract: 目的 研究α-synuclein过表达对多巴胺能神经元核受体相关因子-1 (Nurr1)转录活性的影响及作用机制.方法 PC12细胞转染α-synuclein质粒后,采用双荧光素酶检测方法和Western blot方法分别检测Nurr1转录活性及蛋白水平变化情况.同时检测调控Nurr1转录活性的GSK3β/β-catenin通路中相关信号蛋白水平变化.结果 与对照组相比,α-synuclein过表...
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