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The mechanism of Triterpene acids of loquat on transforming growth factor-β1 (TGF-β1)induced lung fibroblast-myofibroblast transdifferentiation and ERK1/2 signaling way
Pages: 341-346
Year: Issue:  3
Journal: Chinese Pharmacological Bulletin

Keyword:  枇杷叶三萜酸TGF-β1肺纤维化人胚肺成纤维细胞ERKCTGF;
Abstract: 目的 研究枇杷叶三萜酸(Triterpene acids of loquat,TAL)对转化生长因子β1(TGF-β1)刺激人胚肺成纤维细胞转分化、胶原合成及ERK通路的影响.方法 体外培养人胚肺成纤维细胞(HFL-Ⅰ),MTT比色法测定TAL对HFL-Ⅰ细胞的增殖抑制率.RT-PCR检测每组中结缔组织生长因子(connective tissue growth factor,CTGF)、平滑肌肌动...
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