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Effects of progesterone on blood brain barrier permeability and brain edema following hypoxic-ischemic brain damage in newborn rats
Pages: 364-367
Year: Issue:  3
Journal: Chinese Pharmacological Bulletin

Keyword:  孕酮缺氧缺血血脑屏障脑水肿水通道蛋白大鼠;
Abstract: 目的 研究孕酮(PROG)对缺氧缺血性脑损伤(HIBD)新生大鼠血脑屏障(BBB)通透性和脑水肿的作用,并进一步探讨其潜在的机制.方法 7 d龄SD大鼠96只,随机分成4组:正常组、假手术组、缺氧缺血(HI)组和PROG组.建立HIBD动物模型, HI后24 h,伊文思蓝示踪剂检测BBB;干/湿法测定脑含水量;免疫组织化学法观察大脑皮质水孔通道蛋白4(AQP4)表达.结果 正常组和假手术组BBB通...
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