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Reversing mechanism of schizandrin A on multi-drug resistance of K562/ADR, HL60/ADR,MCF-7/ADR cell lines
Pages: 329-334
Year: Issue:  3
Journal: Chinese Pharmacological Bulletin

Keyword:  五味子甲素MDR1MRP1K562/ADR、HL60/ADR、MCF-7/ADR细胞株多药耐药逆转效应;
Abstract: 目的 探讨五味子甲素(schizandrin A or deoxyschizandrin,schA)对白血病细胞K562/ADR、HL60/ADR、乳腺癌细胞MCF-7/ADR多药耐药的逆转作用,并初步探讨其逆转机制.方法 MTT法检测schA对耐药细胞的逆转作用;流式细胞仪检测schA对细胞内柔红霉素、罗丹明-123含量和细胞表面P-gp表达水平的变化;用Real-time PCR方法检测sch...
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