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Effect of polyethylene glycol as adjuvant on hepatitis B virus DNA vaccine in vitro
Author(s): 
Pages: 950-955
Year: Issue:  7
Journal: Acta Microbiologica Sinica

Keyword:  聚乙二醇乙型肝炎病毒(HBV)DNA疫苗体液免疫反应细胞免疫反应;
Abstract: [目的]研究聚乙二醇作为佐剂是否能够增强HBV DNA疫苗体液和细胞免疫效果.[方法]我们将乙型肝炎病毒(HBV)DNA疫苗(pVAX-S2)单独或PEG/pVAX-S2免疫C57BL/6J小鼠,在最后一次免疫14 d检测抗-HBs IgG、T淋巴细胞增殖、细胞因子表达及体内细胞毒T淋巴细胞杀伤作用(CTL)等免疫学指标.[结果]结果表明,与仅免疫pVAX-S2比,PEG/pVAX-S2能够增加免...
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