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Issue:
Effect of polyethylene glycol as adjuvant on hepatitis B virus DNA vaccine in vitro
Author(s):
Junpeng Wang
,
Ligan Lu
,
Hongli Song
,
Yongjie Yang
,
Yuanfang Ma
Pages:
950
-
955
Year:
2010
Issue:
7
Journal:
Acta Microbiologica Sinica
Keyword:
聚乙二醇
;
乙型肝炎病毒(HBV)DNA疫苗
;
体液免疫反应
;
细胞免疫反应
;
Abstract:
[目的]研究聚乙二醇作为佐剂是否能够增强HBV DNA疫苗体液和细胞免疫效果.[方法]我们将乙型肝炎病毒(HBV)DNA疫苗(pVAX-S2)单独或PEG/pVAX-S2免疫C57BL/6J小鼠,在最后一次免疫14 d检测抗-HBs IgG、T淋巴细胞增殖、细胞因子表达及体内细胞毒T淋巴细胞杀伤作用(CTL)等免疫学指标.[结果]结果表明,与仅免疫pVAX-S2比,PEG/pVAX-S2能够增加免...
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